In conclusion, CBD is an excellent alternative to an opioid in chronic pain because CBD is non-intoxicating in its pure form. However, a few studies are showing the benefits of CBD not only for chronic pain but also for sleep improvement and quality of life. Regulations of CBD worldwide differ from each other due to the insufficiency of solid evidence to establish its benefit versus the risks. Inclusion criteria were applied, and quality assessments were done, resulting in 12 publications eligible for the review.ĬBD and tetrahydrocannabinol (THC), both from Cannabis plants with almost identical chemical structures, attach to the CB receptor, eliciting different effects like the psychoactivity seen on THC but less or none in CBD.

Inclusion criteria used were studies on adult populations >18 years old pain symptoms >three months duration all available preparations of CBD human studies only publication in English in the past five years. The systematic review is according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 checklist.įive databases (PubMed, PubMed Central, Medline, Cochrane Library, and ScienceDirect) were searched using cannabidiol, CBD, hemp, and chronic pain.

We conducted a systematic review to determine the efficacy and safety of cannabidiol (CBD) for chronic pain.

Timing synonym